In the sense of the laws of physics being used by humans. The regularity in nature should exist regardless of the existence of people.
1-2g2b1 Constructor Theory defines knowledge independent of people
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Substrate-independence can be only realized by beings which can use symbols
5-1b1a1c4 The interoperability laws (i.e., substrate-independent formulation of information) are more detailed exposition of the Turing principle
10-2g2e1 Our best explanation invokes abstractions including causation and the laws of physics