2-1b2e2 Knowledge doesn't care how it's replicated and its impact on the knowledge bearing entities. What matters is whether the content is replicated, and there's space for creativity and variation here.

3-1a2 The problem itself doesn’t care how it’s solved. Everything should be structured around solving problems.

9-1b1 Ideas are never replicated fully because each individual has different problem-situation. Meme variation (and mutation) is inevitable.
9-1b2 Inevitable meme variation is another reason why it’s impossible to predict how people will use your work and ideas